1- Irritated by Kelly/Samantha telling me that someone would like to talk to me on another deck even though I JUST CAME FROM THAT DECK.
2- Irritated that my FemShep runs like she has a sausage and eggs between her legs even though she's clearly a woman.
3- Annoyed that Shepard is carrying a gun in a cutscene that I didn't equip him with (where did he get it from??).
4- Irritated that the piece of armor that would give me great stats is just plain ugly and would ruin my outfit.
5- Irritated that wearing a helmet would increase my stats but I refuse to wear it because I then can't see my Shepard speak.
6- Upset at having to kill defenseless pyjaks to get a discount from the Krogan store.
7- Irritated that to play Mass Effect 1 again I would have to sit through all that pointless driving around in the goddamn Mako.
8- Annoyed that Jack won't get together with my FemShep even though I thought for sure she'd be the one female in the game that would.
9- Annoyed at Liara for giving me fifty chances to get back with her in ME3 even though I cheated on her in ME2.
10- Frustrated that every time Kai Leng turns up I lose control of my Shepard who suddenly can't shoot for shit.
Got some of your own to share?